Whey, Invokana, and Kidney Pain

Call me crazy, but I was having pretty serious kidney pain a week ago that I believe was caused by the combination of whey and the diabetes medicine Invokana. I remembered that Invokana and whey both can stress the kidneys. If you are taking Invokana and taking whey, that might not be a good thing. I stopped the Invokana and have been taking the whey for a few days now and feel good. If you are having kidney pain and are taking Invokana and whey, you might have your reason right there! Always listen to your body!

Side Effect information for Invokana:

5.3 Acute Kidney Injury and Impairment in Renal Function

INVOKANA causes intravascular volume contraction [see WARNINGS AND PRECAUTIONS (5.1)] and can cause renal impairment [see ADVERSE REACTIONS (6.1)]. There have been postmarketing reports of acute kidney injury, some requiring hospitalization and dialysis, in patients receiving INVOKANA; some reports involved patients younger than 65 years of age.


A high protein diet can stress the kidneys. I was taking 60g of whey per day. No bueno.


Clin J Am Soc Nephrol. 2006 Nov;1(6):1293-9. Epub 2006 Sep 27.

Advanced glycation end products and nephrotoxicity of high-protein diets.

Abstract: The popularity of high-protein diets has surged recently as obesity has become more and more common in the United States and other developed nations. In view of the high prevalence of type 2 diabetes and chronic kidney disease among obese people, it is important to understand potential effects of high-protein diets on the kidney. The hypothesis that high-protein diets are nephrotoxic because of their excessive dietary advanced glycation end product (AGE) content and an increased amino acid load that enhances AGE formation in situ was explored. This review discusses the following evidence: (1) High-protein diets are deleterious to the kidney; (2) AGE are metabolic mediators of kidney damage; (3) dietary protein-derived AGE contribute to proinflammatory and pro-oxidative processes in diabetes and kidney disease; and (4) dietary protein-derived AGE produce functional and structural abnormalities that are involved in kidney damage. Future research should consider dietary AGE as a potential therapeutic target for kidney disease in obesity, diabetes, and perhaps other causes of chronic kidney disease.


William Jiang, MLS is the Author of 63 books, including the bestselling books Guide to Natural Mental Health , 3rd ed and his critically-acclaimed autobiography A Schizophrenic Will: A Story of Madness, A Story of Hope. You can see a selection of his books about mental and physical health nicely laid out on his blog at http://www.mentalhealthbooks.net or check out his Facebook at Mental Health Books.NET