I have survived for more than twenty-five years while taking many antipsychotics. While some atypical antipsychotics are quite good at controlling anger, namely, Clozaril, Zyprexa, and Risperdal, others are not as good. Zyprexa and Risperdal basically block, or are antagonists, at the D2 dopamine receptors and serotonin receptors. They are not partial agonists. Clozaril is a partial agonist at the D2 receptor, but because of a compensatory mechanism with the NMDA receptor, it has both the greatest efficacy against psychosis and anger of any available antipsychotic. Truly, Clozaril is one of a kind. If not for the deadly possibility of Clozaril causing deadly low white blood cell count, I am sure it would be the mainstay of schizophrenia pharmacotherapy around the world. European psychiatrists use Clozaril more than American psychiatrists, and their patients, accordingly, on average live longer and more productive lives. Seroquel, Geodon, and Abilify do not have the same compensatory effect on NMDA, and in my opinion, therein lies the danger of these three partial agonists to cause extreme medication-induced rage
It struck me that Mr. Levine seemed to talk a lot about Seroquel and rage in his first chapter. I survived Seroquel, as detailed in my autobiography A Schizophrenic Will: A Story of Madness, A Story of Hope. I wrote an article titled Is Seroquel Safe? About the sometimes causal relationship between Seroquel and anger, indeed sometimes extreme homicidal anger and rage, years ago, and I am now re-posting it because when my WordPress went down, so did the article.
Many years later, after working really well for many years Abilify eventually made me homicidal and suicidal. I had so much rage on Abilify, eventually my body was shaking for two days straight and I had to use all my will not to explode and kill anyone in the process of letting out the rage. I put myself into the hospital. I went into more depth in my little library science way, and in an article for Psychcentral.org titled Angry? It might be Abilify. I wrote the following: “The ehealthme.com database shows the following drug- percentage chance of causing anger: Abilify – 0.77% ; Geodon – 0.93%; and Seroquel -1%. All of these drugs either modulate dopamine or serotonin. When 1 out of 100 people will notice anger or rage issues, that’s a common side effect, but is is nowhere in the prescribing information for these drugs in the Physician’s Desk Reference. Also, it turns out that the raw number of people who have anger from Abilify on ehealthme.com is higher than Accutane: the famous drug that made the kids go crazy violent in Bowling for Columbine.” This is all public knowledge but, not one of these three drugs has “Anger” or “Rage” as a possible side effect listed anywhere in the prescribing information. I feel this hampers otherwise good doctors from doing their jobs, as anger can also be a side-effect of PTSD or psychosis. So, when rage appears the doctors are not alerted that the side effect of anger, indeed, could be due to the atypical antipsychotic they are prescribing, unwittingly putting lives are risk.- even at the low 2 milligram dose I was taking, even after many years with no problems on the drug.
Author William Jiang, MLS quoted featured on CBS News and in the NEW YORK TIMES
Partial Dopamine and Partial Serotonin Agonists Can Cause Rage
Let me explain the neurobiology of extreme anger and its connection to serotonin and dopamine. When one increases serotonin in a teenager or possibly another person with an SSRI it is well recognized that anger or suicidality may result. Seroquel and Geodon are partial serotonin agonists- they can raise serotonin when it gets low. Also, dopamine is another neurotransmitter involved in anger formation or suppression. Quoting verbatim, the medical researcher Yao Xue Xue Bao. in an article from 1992 titled [Amphetamine–induced rage reaction in mice and its mechanism]. “…Therefore, it may be deduced that the APT-induced rage reaction results from increased release of dopamine in the limbic system “ There are quite a few other articles indexed by MEDLINE that include much of the same information, but not so many are as unequivocally clear that dopamine can cause rage. How does this apply to Abilify? Abilify works with a “Goldilocks” mechanism. When dopamine goes too high, it is blocked, but if it goes too low, it is raised in a mechanism called partial dopamine agonism. So, Abilify can raise dopamine, therefore, increasing dopamine can cause rage: as well-evidenced by a few people who do cocaine as well. Hence, partial dopamine agonism explains why Abilify can cause extreme rage. Partial serotonin agonism explains why Geodon, and Seroquel can cause extreme rage.
For most of the people, most of the time, these drugs work as intended without the side-effect of rage. However, sometimes not.
Popular partial agonists like Abilify, Seroquel, and Geodon are used for treating schizophrenia, PTSD, bipolar disorder, depression, and other psychiatric issues. If you are taking a newer atypical antipsychotic for one of these these issues there is a good chance it is a partial agonist of dopamine or serotonin, possibly to “augment” your antidepressant. Literally, millions of people in the United States alone take these three medications. 1% of just one million people is 10,000 people. To put this in a statistical perspective, when we realize that according to CBS News 1 in 6 Americans take some kind of psychiatric drug and there are about 300 million people in the USA, that means 50 million people are taking psychiatric medicines and Seroquel, Geodon, and Abilify are some of the most popular psychiatric drugs. If only half of one percent of 50 million people is affected by anger that is a staggering 250,000 people who may be put in danger of excessive and dangerous rage.
If it were in my power to magically wave my hand and force this knowledge into the textbooks of young resident doctors and psychiatrists as well as educating the general public in an instant, I would, but I need help spreading this message. I am just one person with a blog. You can help! Please share this essential post to help others! A personal note, I am currently stable with my paranoid schizophrenia on Navane chemical name thiothixene at a very low 10 milligram dose, with a beautiful girlfriend, a good writing career of many books behind me, I am the first in the world to use a Vagus Nerve Stimulator for severe Multiple Chemical Sensitivities, and I am currently looking for gigs as a Spanish to English and English to Spanish Translation and Statistician, my profile is on Upwork.
However, my main goal in life is to help others. So thanks for reading, and please let me know what you think in a comment, and please feel free to link to my blog or this article in particular, if you think it was helpful!
Don’t let them bury me, I need your help!
Look, as I said, I wrote an article a bit after 2000 titled “Is Seroquel Safe?” It got over 10,000 views on Geocities in six months because it was #1 for the keywords “Seroquel Safety” Then, somebody, somewhere made the decision to bury the story. It was buried under money. Six months after it was put up, it went from the #1 position, seemingly overnight, to the 10th page, and then even further down the list. Buried. Let’s be honest. I am a bestselling mental health author who backs everything he says up with hard medical science. But, who am I to the 2017 income of Geodon’s $53 Billion made for Pfizer, Abilify’s $19.4 billion made for Bristol-Myers Squibb, and Seroquel’s more than $25 billion made for Astrazeneca PLC? I am a mote of dust. PLEASE do not let them bury this article! You are seeing it at #1 on Google because Google thinks is an important article. You are seeing it because people are linking to this article, because maybe they know or knew somebody who got angry, enraged, suicidal, homicidal, incarcerated, or worse because of the drug they relied on had an undocumented serious side effect. I, myself, have very strong powers of insight. Most people do not. I have the training of a Columbia Psychiatry Library Chief. Most do not. I was so close to killing or being killed, more than 9 months ago. An update: I went to see my old psychiatrist about his nearly deadly error in insisting on my taking Abilify. He was a gentleman and a true doctor, when he said three times. “Will it seems you were totally right.” I have no problems with this man. I have a problem with the system that he relied on for information. I have a problem with the money. Please, share this page everywhere on your social media: Reddit, Facebook, Twitter, Instagram, Google+, Digg, Orkut, Pinterest. Everywhere. Copy the text of this article to your blog and link to the original, please. I do not want to be buried. I do not want them to cover up this “little problem” that is killing and incarcerating thousands and thousands per year, when it is not the fault of the patient. For more information, I invite you to follow me on Facebook and sign up for email blasts. Very importantly!!! If you are somebody with money and power and you think I can help you help others with this, please contact me. I can do a lot with a little. Salud!
See Author William Jiang, MLS featured
in the NEW YORK TIMES and on CBS National News
William Jiang, MLS is currently the Author of 69 books, including the bestselling books The Medical Librarian’s Guide to Natural Mental Health: Anxiety, Bipolar, Depression, Schizophrenia, and Digital Addiction: Nutrition, and Complementary Therapies, 4th edition and his critically-acclaimed autobiographies A Schizophrenic Will: A Story of Madness, A Story of Hope and William Jiang and the Gamma Core. You can see a selection of his books about mental and physical health nicely laid out on his blog at http://www.mentalhealthbooks.net