Non-invasive vagus nerve stimulation and multiple chemical sensitivity?

I pose the question, could non-invasive vagus nerve stimulation help multiple chemical sensitivity? See: ElectroCore’s GammaCore, not yet FDA Approved: http://gammacore.com

 

AbstractBrain Stimul. 2014 Nov-Dec;7(6):871-7. doi: 10.1016/j.brs.2014.07.031. Epub 2014 Jul 16.Non-invasive vagus nerve stimulation and multiple chemical sensitivity

Non-invasive vagus nerve stimulation in healthy humans reduces sympathetic nerve activity.

Clancy JA1, Mary DA1, Witte KK1, Greenwood JP1, Deuchars SA2, Deuchars J3.

Author information

 

Abstract

BACKGROUND:

Vagus nerve stimulation (VNS) is currently used to treat refractory epilepsy and is being investigated as a potential therapy for a range of conditions, including heart failure, tinnitus, obesity and Alzheimer’s disease. However, the invasive nature and expense limits the use of VNS in patient populations and hinders the exploration of the mechanisms involved.

OBJECTIVE:

We investigated a non-invasive method of VNS through electrical stimulation of the auricular branch of the vagus nerve distributed to the skin of the ear–transcutaneous VNS (tVNS) and measured the autonomic effects.

METHODS:

The effects of tVNS parameters on autonomic function in 48 healthy participants were investigated using heart rate variability (HRV) and microneurography. tVNS was performed using a transcutaneous electrical nerve stimulation (TENS) machine and modified surface electrodes. Participants visited the laboratory once and received either active (200 μs, 30 Hz; n = 34) or sham (n = 14) stimulation.

RESULTS:

Active tVNS significantly increased HRV in healthy participants (P = 0.026) indicating a shift in cardiac autonomic function toward parasympathetic predominance. Microneurographic recordings revealed a significant decrease in frequency (P = 0.0001) and incidence (P = 0.0002) of muscle sympathetic nerve activity during tVNS.

CONCLUSION:

tVNS can increase HRV and reduce sympathetic nerve outflow, which is desirable in conditions characterized by enhanced sympathetic nerve activity, such as heart failure. tVNS can therefore influence human physiology and provide a simple and inexpensive alternative to invasive VNS.

MCS and Yoga

To understand how MCS and Yoga are linked, one has to understand the Vagus nerve and the Parasympathetic Nervous Systemmcs and yoga

The parasympathetic nervous system (abbreviated PN to avoid confusion with the peripheral nervous system (PNS)) is one of the two divisions of the autonomic nervous system, the other being the sympathetic nervous system.[1] The autonomic nervous system is responsible for regulating the body’s unconscious actions. The parasympathetic system is responsible for stimulation of “rest-and-digest” or “feed and breed”[2]activities that occur when the body is at rest, especially after eating, including sexual arousal, salivation, lacrimation (tears), urination, digestionand defecation. Its action is described as being complementary to that of the sympathetic nervous system, which is responsible for stimulating activities associated with the fight-or-flight response.
Nerve fibres of the parasympathetic nervous system arise from the central nervous system. Specific nerves include several cranial nerves, specifically the oculomotor nerve, facial nerve, glossopharyngeal nerve, and vagus nerve. Three spinal nerves in the sacrum (S2-4) also act as parasympathetic nerves. These are commonly referred to as the pelvic splanchnic nerves.

from: http://en.m.wikipedia.org/wiki/Parasympathetic_nervous_system

In my opinion, the best treatment using for mcs using yoga and the parasympathetic nervous system that I have found that is free on Youtube, is the following video. The most powerful part of the video is the yogic breathing technique, it looks like a reverse Ujjayi breath. I learned the Ujjayi breath from a Chinese Yoga Breathwork Teacher in NYC. So anyways, this breath near the end of the video calms the parasympathetic system using the vagus nerve. It is a VERY POWERFUL technique. Also grounding and meditation can possibly help calm the overactive parasympatheic systems, over time.

 

It turns out that according to Annie Hopper, the Cytochrome P450, the limbic system, and the vagus nerve are somehow related. Don’t ask me how. I’m just a librarian. However, I do know that I did talk earlier about how Cytochrome P450 and limbic system dysfunction caused by a mix of wellbutrin and Abilify caused my MCS.

Taurine and MCS Multiple Chemical Sensitivity

Taurine and MCS seem be linked somehow. I have been supplementing with Taurine for the last three weeks. My MCS has been significantly improved, however, it now seems I am somehow sensitivite to Taurine. Last night I went to the ER to check checked for chest pains and dizziness. I am taking 500 mg of Taurine per day which is half the amount of taurine in a Red Bull Energy Drink. This is something researchers should look into. I am going to bring out a few points as to why I think Taurine is important in MCS.
The following story in Medical News Today reminded me of the relationship between many depressed people and MCS.

Douglas study on neurogenesis in the olfactory bulbtaurine and mcs

Towards a better understanding of the mechanisms of depression

A new study published by the team of Naguib Mechawar, Ph.D., a researcher at the Douglas Institute (CIUSSS de l’Ouest-de-l’île-de-Montréal) and Associate Professor in the Department of Psychiatry at McGill University, suggests that the integration of new neurons in the adult brain is a phenomenon more generally compromised in the brains of depressed patients.

This new work confirms that neurogenesis in the human olfactory bulb is a marginal phenomenon in adults. These findings shed light on the special features of the human brain.

I checked and taurine is abundant in the olfactory bulb.
Chem Senses. 2004 Jan;29(1):83-91.
Taurine action on mitral cell activity in the frog olfactory bulb in vivo.
Chaput MA1, Palouzier-Paulignan B, Delaleu JC, Duchamp-Viret P.
Abstract
Taurine (TAU) is a free amino acid that is particularly abundant in the olfactory bulb. In the frog, TAU is located in the terminations of the primary olfactory axons and in the granular cell layer. TAU action seems to be associated with gamma amino butyric acid (GABA), the main inhibitory neurotransmitter involved in the processing of the sensory signal. The present study was designed to assess the action of TAU in vivo during the olfactory network’s stimulation by odors. It was performed by recording the single-unit activity of mitral cells, the main bulbar output neurons. TAU effects were tested on both their spontaneous and odor-induced firing activity. Interactions between TAU and GABA were examined by analyzing TAU effects under the selective blocking action of GABAA or GABAB antagonists. TAU was found to suppress the spontaneous firing of mitral cells, mainly without altering their odor response properties. By testing GABA antagonists, we further show that TAU action is associated with GABAergic inhibitory mechanisms mainly via GABAB receptors. Thus, TAU action clearly reduces background activity in favor of the emergence of the odor-induced activity in the same manner as GABA action does via GABAB receptors. As a conclusion, we propose that, in the frog olfactory bulb, the joint actions of TAU and GABA may favor the processing of the primary sensory information by increasing the signal to noise ratio.
Turns out taurine is good for neurogenesis. With more the creation of more brain cells, depression is made better.
Stem Cell Res. 2012 Jul;9(1):24-34. doi: 10.1016/j.scr.2012.02.004. Epub 2012 Mar 7.
Taurine stimulates proliferation and promotes neurogenesis of mouse adult cultured neural stem/progenitor cells.
Hernández-Benítez R1, Ramos-Mandujano G, Pasantes-Morales H.
Author information
Abstract
This study reports an effect of taurine (1-10 mM) increasing markedly (120%) the number of neural precursor cells (NPCs) from adult mouse subventricular zone, cultured as neurospheres. This effect is one of the highest reported for adult neural precursor cells. Taurine-containing cultures showed 73-120% more cells than controls, after 24 and 96 h in culture, respectively. Taurine effect is due to enhanced proliferation as assessed by BrdU incorporation assays. In taurine cultures BrdU incorporation was markedly higher than controls from 1.5 to 48 h, with the maximal difference found at 1.5 h. This effect of taurine reproduced at every passage with the same window time. Taurine effects are not mimicked by glycine, alanine or GABA. Clonal efficiency values of 3.6% for taurine cultures and 1.3% for control cultures suggest a taurine influence on both, progenitor and stem cells. Upon differentiation, the proportion of neurons in control and taurine cultures was 3.1% (±0.5) and 10.2% (±0.8), respectively. These results are relevant for taurine implication in brain development as well as in adult neurogenesis. Possible mechanisms underlying taurine effects on cell proliferation are discussed.
Also there is a theory that there is a dysfunction in the NMDA receptor in MCS. Taurine is good for this.

Eur J Pharmacol. 2014 Apr 5;728:167-75. doi: 10.1016/j.ejphar.2014.01.025. Epub 2014 Jan 28.
Modes of direct modulation by taurine of the glutamate NMDA receptor in rat cortex.
Chan CY1, Sun HS2, Shah SM2, Agovic MS3, Friedman E1, Banerjee SP4.
Author information
Abstract
Taurine is an endogenous brain substance with robust neuromodulatory and possible neuroprotective properties. Though other mechanisms of action have been reported, its interaction with the NMDA (N-methyl-D-aspartic acid) receptor is undocumented. We investigated taurine’s interaction with the NMDA receptor using electrophysiological and receptor binding approaches. The effects of taurine on field potential responses in layer-5 of prelimbic cortex in rat brain slices evoked by single-pulse electrical stimulation of ventral medial cortex were determined. Picrotoxin (80 µM) was present in all control and drug solutions to block the Cl(-) channels associated with the GABA-, taurine-, and strychnine sensitive glycine- receptors. A typical response consisted of an NBQX (2,3-dioxo-6-nitro-1,2,3,4-tetrahydrobenzo-[f]-quinoxaline-7-sulfonamide)-sensitive negative wave (N1) followed by a positive wave (P1) and a broad negativity (N2), both sensitive to dl-AP5 (dl-2-amino-5-phosphonopentanoic acid) inhibition. Taurine exerted a 41.5 ± 8.3% (n = 9) voltage reduction within the late phase of N2. This taurine action was prevented by 100 µM AP5, but not by 10 µM nifedipine, supporting a direct modulation of NMDA receptor function by taurine, without requiring the involvement of the L-type Ca(2+) channel. Taurine did not alter specific [(3)H] MK-801 binding to rat cortical membranes in the presence of glycine or glutamate; but inhibited spermine-potentiated specific [(3)H] MK-801 binding to NMDA receptors by 15-20% in the presence of glycine. In addition, taurine reduced the apparent affinity of the NMDA receptor for glycine (in the presence of spermine) by 10-fold. These results show that taurine interacts directly with the NMDA receptor by multiple mechanisms.

An earlier post of mine talked about the dangers of mixing Abilify and Wellbutrin. The mix can cause limbic seizures. The mix caused my MCS. Turns out taurine inhibits the limbic epileptic seizure threshold.
Taurine and epilepsy.
Oja SS1, Saransaari P.
Abstract
Dysfunction of excitatory and inhibitory neurotransmitters or neuromodulators is thought to underlie epileptic symptoms. Taurine, 2-aminoethanesulfonate, is a ubiquitous free amino acid abounding in the brain of humans and most animal species. It hyperpolarizes neurons and inhibits their firing. It may be a participating factor in certain subpopulations of epilepsy patients but its deficiency is not a universal prerequisite for seizures. Here, the participation of taurine in animal seizure models and human epilepsy patients is reviewed.

Epilepsy Res. 2013 May;104(3):187-94. doi: 10.1016/j.eplepsyres.2013.01.010. Epub 2013 Feb 12.
Dr. Nagy attributes, in part, her recovery from MCS to taurine:
Overcoming Electrical Sensitivity Success Stories—Dr. Lisa Nagy Successful Treatment of my Chemical and Electrical Sensitivity
Giving supplements (Vitamin C, B, Glutathione etc) that assist in breaking down these chemicals faster—more of the ones that are missing genetically. Fish Oil, Magnesium, Co Q 10, E, selenium, taurine—nothing crazy.

I wish I could continue to take taurine regularly because it has given me much life back, but it seems a bit risky. I just wanted to share what I know. I’ll be starting B6 today because it tuns out many people with MCS are B6 deficient which in turn leads to a deficiency of taurine.

Kindle Book Sale- 90% off best selling #mentalhealth books for a limited time!

Kindle Book Sale!

Due to a upcoming BookGorilla.com Amazon Kindle Book Sale, you can get the best-selling books A Schizophrenic Will: A Story of Madness, A Story of Hope and Guide to Natural Mental Health: Anxiety, Bipolar, Depression, Schizophrenia, and Digital Addiction: Nutrition, and Complementary Therapies for only 99 cents each on the Kindle,  for a limited time! That is up to more than $34 off the print edition! When the promotion is over, it’s over! Get them at this price while you can!

ITI-007 for schizophreniaAbout Guide to Natural Mental Health: Anxiety, Bipolar, Depression, Schizophrenia, and Digital Addiction: Nutrition, and Complementary Therapies

The thrust of this book is nutrition and complementary therapies for digital addiction, anxiety, bipolar, depression, and schizophrenia. Truisms that have been passed down through the ages about mental health that have stood the rigors of scientific inquiry are presented. The role of nutrition in ameliorating anxiety is discussed. Light is thrown on the benefits of meditation, yoga, aromatherapy, exercise, the healing power of music, and the detrimental effects of playing too many video games or viewing too much pornography on depression. Next, the role of nutrition in helping manage bipolar disorder is included. The effect of light on bipolar disorder and the importance of good sleep hygiene is underlined. Then, how nutrition affects depression is discussed. A question relevant to many of us, “What are the effects of being indoors all the time?” is delved into. A long list of things that can be helpful for ameliorating depression is presented including: natural herbal remedies, meditation, religion, yoga, the effect of too much or too little light, the role of exercise in fighting depression, the role of music on the mood, the role of a positive social network in recovery, the role of pets, the harmful effects of the digital lives we lead, and the healing power of scent. Finally, the amazing fact that nutrition can sometimes prevent psychosis in its beginning stages before it becomes fully-blown schizophrenia is looked at. Additional mental health tips added to third edition.

About A Schizophrenic Will: A Story of Madness, A Story of Hopemental health books

“A Schizophrenic Will: A Story of Madness, A Story of Hope” is an inspirational autobiographical account of living with the dreaded disease of schizophrenia. His story is one of rare genius, olympian strength, torrid romance, academic dominance, and, finally, professional accomplishment. Mr. Jiang leads us on a journey that chronicles twenty years of his life. The journey begins with his first serious psychotic break from reality as a teenager and ends with him being a respected, published medical library Chief at the number one psychiatric research institute in the world, NYSPI, affiliated with Columbia University. One thing that makes his story a wonder to read is the sheer number of challenges he faces head-on and, ultimately, overcomes. Mr. Jiang’s story is an unforgettable, uplifting personal history to be read and savored. Not only is his autobiography difficult to put down once picked up, but A Schizophrenic Will: A Story of Madness, A Story of Hope leaves the reader wanting more, after the tale is told.

How to Shop Online Like a Boss: Free – Learn and Save!

The Exciting New Book!shopping online like a boss

My new book is How to Shop Online Like a Boss, I’m looking for people to rate and review on Amazon. Just join Kindle Unlimited, and  you got it!  I guarantee you will find it a good read and make you a world-class online shopper. If you take your time and send me your review and it’s really cool, I might even feature your review  on Amazon!

 

From Amazon: “Let’s face it is not typically the domain of men, yet it is not rocket science. Intelligent shopping can be learned. When we go shopping, stereotypically, the male goes to the store like a hunter focused on his prey. We swoop into the store, grab our items, and we are out– fast. Then, we go to the bar with the guys. I hate to say it, but this is not the way to do shopping right. E-Mail alerts, the Big Four online outlets, RSS, Meta Search, and more can save you thousands. I can show you the light. And, ladies, I promise you, you won’t be ripped off easily while shopping again after reading this short introduction to online shopping. Everyone reading this book can save mucho money fast, using the e-commerce techniques of a former Columbia University Library Chief.”

Check it out at:

http://www.amazon.com/How-Shop-Online-like-Boss-ebook/dp/B00YB0VW4S/ref=sr_1_1?s=books&ie=UTF8&qid=1432698721&sr=1-1&keywords=how+to+shop+like+a+boss

Esquizofrenia Biografia: Cinco Estrellas! Por William Jiang, MLS

Por Grady Harp AMAZON HALL DE FAMETOP 100 REVIEWER Y VINE VOZ

Entre la Esquizofrenia y Mi Voluntad: Una Historia de Locura y Esperanza

Este crónica extraordinaria de William Jiang de su vida es a la vez arrestando, horrible, desafiante y estimulante. Obviamente Will Jiang esquizofrenia biografiaes un hombre joven y brillante nacido prematuramente a una madre anglosajona y un padre judío ruso ausente y posteriormente adoptado por su padrastro chino Jiang Yu: los recuerdos conmovedores de des mesuradamente y homenajes de sus hermanos Hoja, Chung y Justicia, así como los comentarios introducidos en su prefacio forman una impresionante lista de personas atestiguar al hecho de que se trata de un joven único.

Pero la razón esta autobiografía es tan conmovedora es el hecho de que Will Jiang fue diagnosticado a los 19 años como un esquizofrénico paranoico y dado el hecho de que él es bien educado (ha obtenido una licenciatura y maestría de anuncios de Bibliotecología, habla cuatro idiomas, que se sirve como la Jefe del Biblioteca de la Universidad de Columbia / NYSPI y ha escrito una serie de libros finos), la manera en que él es capaz de no reportar como un espectador del funcionamiento de la mente se hunde en las profundidades psicóticos sino relativa al lector la sensación de ese descenso, tratamiento, horrores, y la eventual recuperación es poco menos que sorprendente.

Este libro nos lleva de la mano y nos guía a través de las primeras sugerencias de la enfermedad mental, nos sumerge en el momento a momento pesadillas que asalto la mente de un paciente esquizofrénico, nos hace sentir los efectos de los medicamentos y tratamientos, y luego nos llama a la luz y su propio descubrimiento de técnicas nutricionales naturales que ayudan a sanar el cerebro. Es una odisea, la lectura de este libro, pero también es una ventaja de viaje por un guía que conoce a cada aspecto de ella también.
Will Jiang escribe tan bien que se espera que va a abrazar a su regalo por su talento literario y continuar escribiendo obras mayores. Él es un hombre extraordinario que está haciendo más para educar al público sobre el mundo de las víctimas enfermos mentales mientras que proporciona una brillante luz de esperanza. Muy Recomendado. Grady Harp, 14 de Agosto

Guía de Salud Mental Natural, tercera edición: Cinco Estrellas de Amazon Top Crítico Sr. Grady Harp!

Critica del Guía de Salud Mental Natural por Grady Harp

Amazon SALÓN DE LA FAMA TOP 100 revisores y VOZ VINE

Formato: Versión Kindle

Para los lectores nuevos de William Jiang, su siguiente libro es muy recomendado: Guia de salud mental naturalEntre la Esquizofrenia y Mi Voluntad: Una Historia de Locura y Esperanza William Jiang era el Jefe de la Biblioteca del Pacientes al Instituto Psiquiátrico del Estado de Nueva York, afiliado con la Universidad de Columbia, por siete años. Este libro se centra en el conocimiento acerca de los tratamientos complementarios y alternativos de la salud para determinados problemas mentales que él recogido más de siete años de seguir la literatura de salud mental durante ese epoca. La idea central del libro es la salud mental, nutrición y terapias complementarias.

En uno de los libros más completos hasta la fecha acerca de los tratamientos naturales de las desviaciones de salud mental constituyen la norma, William Jiang deja muy claro cómo cada uno de los muchos problemas de salud mental que crecen en número cada día se puede tratar de forma natural. Además de los problemas habituales que esperaríamos a tratar, Jiang ofrece una mirada esclarecedora en Adicción digital – y el libro es bien vale la pena la compra simplemente para este acercamiento muy válido.

Jiang escribe muy bien y ofrece una perspectiva diferente sobre la manera de pensar y la forma de hacer frente y cómo tratar o prevenir los trastornos mentales. La salud es su meta y lo presenta así. Como afirma al final del libro, `Como la tecnología se vuelve más y más en nuestros huesos, estamos perdiendo algunos de los ritmos naturales de la vida. A pesar de estar en interiores en ambientes climatizados, nuestras mentes y cuerpos todavía están inexorablemente ligados al cambio de las estaciones “.

Grady Harp 14 de noviembre

Premier edicion del Guia disponible en español: La guía del Bibliotecario Médico: Ansiedad, Depresión, Bipolar, y Esquizofrenia: Nutrición y Terapias Complementarias 

Santa Dymphna: Patróna Santa de los Enfermos Mentales

El 15 de mayo es el día de Santa Dymphna, la patrona de los enfermos mentales. Santa Dymphna en la leyenda popular es la hija de un jefe celta pagano llamado Damon. Dymphna era cristiana. Se cree que murió alrededor de 650 dC Ella salió corriendo de su casa con su confessor, San Gerebernus y dos compañeros después de la muerte de su madre para que ella pudiera escapar el interés incestuosa de su padre.Santa Dymphna Patrona del Enfermos Mentales

Hay dos escenarios para explicar por qué el padre de Dymphna tenía ese interés incestuosa por su hija. Ambos escenarios muestran que el rey se volvió loco después de la muerte de su esposa. El primer escenario fue que después de buscar a través de todo el reino para una mujer tan buena y hermosa como su difunta esposa, se dio cuenta de que esta hija era la única que podía tomar el lugar de su difunta esposa. El segundo escenario es que trató de casarse con su hija porque él pensó que era lo mejor que puede hacer por la estabilidad política en sus tierras.

santa dymphnaSan Gerebernus, Dymphna, y sus dos acompañantes huyeron a Amberes, y construyeron un oratorio en Gheel, cerca de Amsterdam, donde vivían como ermitaños. El padre de Dymphna los encontró en un número de meses, y sus hombres puso el sacerdote y dos compañeros a la muerte, mientras que Dymphna fue decapitado por su propio padre, porque ella se negó a regresar con él a sus tierras. Cuando se descubrieron los cuerpos de Dymphna y Gerebernus en Gheel en el siglo 13, cura para los epilépticos, los locos y los poseídos fueron reportados muchos en número. Santa Dymphna es la patróna de los epilépticos y los que sufren de enfermedades mentales. Sus reliquias se reportan para curar la locura y la epilepsia. Cuando la antigua iglesia de San Dymphna en Gheel fue destruido por un incendio en 1489 que fue sustituido por una nueva iglesia, que fue consagrada en 1532.

Bajo el patrocinia de Dymphna, los habitantes de Gheel han sido conocidos por la atención que han prestado a las personas con enfermedades mentales. Al final del siglo 13, una enfermería fue construida. Hoy la ciudad posee un sanatorio de primera clase, una de las colonias más grandes y más eficientes para los enfermos mentales en el mundo. Gheel fue uno de los primeros en iniciar un programa donde los habitantes insanos llevan una vida normal y útiles en los hogares de los agricultores o los residentes locales. La fuerza de culto de Dymphna se evidencia en este trabajo compasivo del pueblo de Gheel para los enfermos mentales en un momento en que fueron universalmente descuidados o tratados con hostilidad.

Este artículo es reproducido del archivo de New York City Voices La direccion de su blog esta http://newyorkcityvoices.blogspot.com/