Taurine and MCS seem be linked somehow. I have been supplementing with Taurine for the last three weeks. My MCS has been significantly improved, however, it now seems I am somehow sensitivite to Taurine. Last night I went to the ER to check checked for chest pains and dizziness. I am taking 500 mg of Taurine per day which is half the amount of taurine in a Red Bull Energy Drink. This is something researchers should look into. I am going to bring out a few points as to why I think Taurine is important in MCS.
The following story in Medical News Today reminded me of the relationship between many depressed people and MCS.
Towards a better understanding of the mechanisms of depression
A new study published by the team of Naguib Mechawar, Ph.D., a researcher at the Douglas Institute (CIUSSS de l’Ouest-de-l’île-de-Montréal) and Associate Professor in the Department of Psychiatry at McGill University, suggests that the integration of new neurons in the adult brain is a phenomenon more generally compromised in the brains of depressed patients.
This new work confirms that neurogenesis in the human olfactory bulb is a marginal phenomenon in adults. These findings shed light on the special features of the human brain.
I checked and taurine is abundant in the olfactory bulb.
Chem Senses. 2004 Jan;29(1):83-91.
Taurine action on mitral cell activity in the frog olfactory bulb in vivo.
Chaput MA1, Palouzier-Paulignan B, Delaleu JC, Duchamp-Viret P.
Taurine (TAU) is a free amino acid that is particularly abundant in the olfactory bulb. In the frog, TAU is located in the terminations of the primary olfactory axons and in the granular cell layer. TAU action seems to be associated with gamma amino butyric acid (GABA), the main inhibitory neurotransmitter involved in the processing of the sensory signal. The present study was designed to assess the action of TAU in vivo during the olfactory network’s stimulation by odors. It was performed by recording the single-unit activity of mitral cells, the main bulbar output neurons. TAU effects were tested on both their spontaneous and odor-induced firing activity. Interactions between TAU and GABA were examined by analyzing TAU effects under the selective blocking action of GABAA or GABAB antagonists. TAU was found to suppress the spontaneous firing of mitral cells, mainly without altering their odor response properties. By testing GABA antagonists, we further show that TAU action is associated with GABAergic inhibitory mechanisms mainly via GABAB receptors. Thus, TAU action clearly reduces background activity in favor of the emergence of the odor-induced activity in the same manner as GABA action does via GABAB receptors. As a conclusion, we propose that, in the frog olfactory bulb, the joint actions of TAU and GABA may favor the processing of the primary sensory information by increasing the signal to noise ratio.
Turns out taurine is good for neurogenesis. With more the creation of more brain cells, depression is made better.
Stem Cell Res. 2012 Jul;9(1):24-34. doi: 10.1016/j.scr.2012.02.004. Epub 2012 Mar 7.
Taurine stimulates proliferation and promotes neurogenesis of mouse adult cultured neural stem/progenitor cells.
Hernández-Benítez R1, Ramos-Mandujano G, Pasantes-Morales H.
This study reports an effect of taurine (1-10 mM) increasing markedly (120%) the number of neural precursor cells (NPCs) from adult mouse subventricular zone, cultured as neurospheres. This effect is one of the highest reported for adult neural precursor cells. Taurine-containing cultures showed 73-120% more cells than controls, after 24 and 96 h in culture, respectively. Taurine effect is due to enhanced proliferation as assessed by BrdU incorporation assays. In taurine cultures BrdU incorporation was markedly higher than controls from 1.5 to 48 h, with the maximal difference found at 1.5 h. This effect of taurine reproduced at every passage with the same window time. Taurine effects are not mimicked by glycine, alanine or GABA. Clonal efficiency values of 3.6% for taurine cultures and 1.3% for control cultures suggest a taurine influence on both, progenitor and stem cells. Upon differentiation, the proportion of neurons in control and taurine cultures was 3.1% (±0.5) and 10.2% (±0.8), respectively. These results are relevant for taurine implication in brain development as well as in adult neurogenesis. Possible mechanisms underlying taurine effects on cell proliferation are discussed.
Also there is a theory that there is a dysfunction in the NMDA receptor in MCS. Taurine is good for this.
Eur J Pharmacol. 2014 Apr 5;728:167-75. doi: 10.1016/j.ejphar.2014.01.025. Epub 2014 Jan 28.
Modes of direct modulation by taurine of the glutamate NMDA receptor in rat cortex.
Chan CY1, Sun HS2, Shah SM2, Agovic MS3, Friedman E1, Banerjee SP4.
Taurine is an endogenous brain substance with robust neuromodulatory and possible neuroprotective properties. Though other mechanisms of action have been reported, its interaction with the NMDA (N-methyl-D-aspartic acid) receptor is undocumented. We investigated taurine’s interaction with the NMDA receptor using electrophysiological and receptor binding approaches. The effects of taurine on field potential responses in layer-5 of prelimbic cortex in rat brain slices evoked by single-pulse electrical stimulation of ventral medial cortex were determined. Picrotoxin (80 µM) was present in all control and drug solutions to block the Cl(-) channels associated with the GABA-, taurine-, and strychnine sensitive glycine- receptors. A typical response consisted of an NBQX (2,3-dioxo-6-nitro-1,2,3,4-tetrahydrobenzo-[f]-quinoxaline-7-sulfonamide)-sensitive negative wave (N1) followed by a positive wave (P1) and a broad negativity (N2), both sensitive to dl-AP5 (dl-2-amino-5-phosphonopentanoic acid) inhibition. Taurine exerted a 41.5 ± 8.3% (n = 9) voltage reduction within the late phase of N2. This taurine action was prevented by 100 µM AP5, but not by 10 µM nifedipine, supporting a direct modulation of NMDA receptor function by taurine, without requiring the involvement of the L-type Ca(2+) channel. Taurine did not alter specific [(3)H] MK-801 binding to rat cortical membranes in the presence of glycine or glutamate; but inhibited spermine-potentiated specific [(3)H] MK-801 binding to NMDA receptors by 15-20% in the presence of glycine. In addition, taurine reduced the apparent affinity of the NMDA receptor for glycine (in the presence of spermine) by 10-fold. These results show that taurine interacts directly with the NMDA receptor by multiple mechanisms.
An earlier post of mine talked about the dangers of mixing Abilify and Wellbutrin. The mix can cause limbic seizures. The mix caused my MCS. Turns out taurine inhibits the limbic epileptic seizure threshold.
Taurine and epilepsy.
Oja SS1, Saransaari P.
Dysfunction of excitatory and inhibitory neurotransmitters or neuromodulators is thought to underlie epileptic symptoms. Taurine, 2-aminoethanesulfonate, is a ubiquitous free amino acid abounding in the brain of humans and most animal species. It hyperpolarizes neurons and inhibits their firing. It may be a participating factor in certain subpopulations of epilepsy patients but its deficiency is not a universal prerequisite for seizures. Here, the participation of taurine in animal seizure models and human epilepsy patients is reviewed.
Epilepsy Res. 2013 May;104(3):187-94. doi: 10.1016/j.eplepsyres.2013.01.010. Epub 2013 Feb 12.
Dr. Nagy attributes, in part, her recovery from MCS to taurine:
Overcoming Electrical Sensitivity Success Stories—Dr. Lisa Nagy Successful Treatment of my Chemical and Electrical Sensitivity
Giving supplements (Vitamin C, B, Glutathione etc) that assist in breaking down these chemicals faster—more of the ones that are missing genetically. Fish Oil, Magnesium, Co Q 10, E, selenium, taurine—nothing crazy.
I wish I could continue to take taurine regularly because it has given me much life back, but it seems a bit risky. I just wanted to share what I know. I’ll be starting B6 today because it tuns out many people with MCS are B6 deficient which in turn leads to a deficiency of taurine.