Abilify and Wellbutrin safety? A bad combination!
According to Drugs.com there is a major Drug Contraindication between bupropion, brand name Wellbutrin, and aripiprazole, brand name Abilify:
Interactions between your selected drugs
bupropion ↔ aripiprazole
Applies to:Wellbutrin (bupropion) and Abilify (aripiprazole)
Talk to your doctor before using buPROPion together with ARIPiprazole. Combining these medications may increase the risk of seizures, which may occur rarely with either medication. In addition, buPROPion can increase the blood levels of ARIPiprazole, which may increase other side effects. You may be more likely to experience seizures with these medications if you are elderly, undergoing alcohol or drug withdrawal, have a history of seizures, or have a condition affecting the central nervous system such as a brain tumor or head trauma. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. You should avoid or limit the use of alcohol during treatment. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
In addition to the widely known seizure contraindication, mixing Abilify and Wellbutrin can, in rare cases, cause multiple chemical sensitivity, MCS. Why? First, one of the major foci for many kinds of adult epilepsy is the limbic area of the brain. The limbic system has also been implicated in the etiology of Multiple Chemical Sensitivity as well. This is too close a link to be ignored.
Also, Abilify and Wellbutrin are metabolized in the liver using cytochrome P450 at the exact same enzymatic location, the CYP2D6 location. For those who are unfamiliar with Multiple Chemical Sensitivity, MCS can be totally incapacitating much like Gulf War Syndrome of the combat Vets from the first Gulf War. Imagine breathing in air that everybody else is breathing, but you have a major physical reaction such as choking or hives, but you do not know what is wrong. It could be Multiple Chemical Sensitivity. Chemicals in the air are everywhere in today’s society, from your favorite restaurant to your local transportation system. As you can easily imagine, MCS can cripple a life.
Wellbutrin and Abilify have opposite effects on the cytochrome P450 CYP2D6 location of the liver, see http://en.wikipedia.org/wiki/CYP2D6 . In fact, when you see the table on Wikipedia, Wellbutrin is a STRONG Inhibitor of CYP2D6. See the following partial list of antipsychotics that also work on the CYP2D6 location , e.g.
Corroborating this cytochrome P450 CYP2D6 link with Multiple Chemical Sensitivity, see the below snippet from MEDLINE:
Xenobiotic sensor- and metabolism-related gene variants in environmental sensitivity-related illnesses: a survey on the Italian population.
3.3. Analysis of CYP2D6 Genetic Background and Risk for Disease
The analysis of genetic background at the CYP2D6 gene locus showed that the CYP2D6*4 was the most represented gene variant in all subgroups of SRI (Sensitivity-Related Illness) cases compared with the CYP2D6*41; moreover, this latter variant was absent in the control population.
If you have MCS one resource to check out is http://mcshousingnmore.com
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